Kristoffer has been working with phase IV clinical trials and real-life evidence for Bandim Health Project, Statens Serum Institut and Technical University of Denmark since he obtained his MSc degree in Biology from Copenhagen University (2010).
Primarily focusing on the tuberculosis vaccine BCG, Kristoffer has continuously pursued the exploration of the real-life effects on general health and disease of approved early life vaccines, with a particular interest in the youngest population, sex-differential outcomes and the interactions with other health interventions.
A large number of studies primarily from low-income countries find that some routine childhood vaccines, including BCG, non-specifically reduce morbidity and all-cause mortality from other diseases than the specific target disease. To improve our understanding of the non-specific beneficial effects of BCG on all-cause neonatal mortality, Kristoffer has conducted epidemiological studies on the temporal, seasonal, sex-differential and formulation-specific dependency of the vaccine effects.
During his PhD, exploring the biological mechanisms behind the beneficial non-specific effects, Kristoffer collected and analysed blood samples from Guinea-Bissau infants for inflammatory cytokine signatures.
Taking the observations of non-specific effects of vaccines from humans to a veterinary setting, at Technical University of Denmark (post.doc. 2015-2018) Kristoffer has conducted biological experimental studies of veterinary vaccines in pigs as well as a randomized study in a large commercial cohort of pigs.
Jensen KJ, Hansen MS, Heegaard PMH, Benn CS, Jungersen G (2019) The Effect of Inactivated Mycobacterium Paratuberculosis Vaccine on the Response to a Heterologous Bacterial Challenge in Pigs. Front Immunol 10: 1557.
Biering-Sorensen S, Jensen KJ, Monterio I, Ravn H, Aaby P, Benn CS (2018) Rapid Protective Effects of Early BCG on Neonatal Mortality Among Low Birth Weight Boys: Observations From Randomized Trials. J Infect Dis 217: 759-766.
Jensen KJ, Ndure J, Plebanski M, Flanagan KL (2015) Heterologous and sex differential effects of administering vitamin A supplementation with vaccines. Transactions of the Royal Society of Tropical Medicine and Hygiene 2014/12/06: 36-45.
Biering-Sorensen S, Jensen KJ, Aamand SH, Blok B, Andersen A, Monteiro I, Netea MG, Aaby P, Benn CS, Haslov KR (2015) Variation of growth in the production of the BCG vaccine and the association with the immune response. An observational study within a randomised trial. Vaccine 33: 2056-2065.
Jensen KJ, Larsen N, Biering-Sorensen S, Andersen A, Eriksen HB, Monteiro I, Hougaard D, Aaby P, Netea MG, Flanagan KL, Benn CS (2014) Heterologous immunological effects of early BCG vaccination in low-birth weight infants in Guinea-Bissau: a randomized-controlled trial. The Journal of infectious diseases 2014/09/12.